Associate Synthetic Chemist Ensemble Discovery
Ensemble Therapeutics Corporation is conducting original research aimed at identifying
novel macrocyclic therapeutic agents against challenging drug discovery targets.
Currently we are seeking a highly motivated and skilled synthetic organic chemist to join
the medicinal chemistry team. The ideal candidate will feel at home in a fast-paced and
multi-disciplinary biotech environment, working independently within a results-focused
Responsibilities will include:
? Design of multi-step syntheses of intermediates, building blocks and final
? The use of solid-phase and solution chemistry techniques
? The thorough purification and characterization of synthetic products.
? Accurate and comprehensive recording of experimental work and presentation of
results to work colleagues.
This position requires a talented synthetic chemist with an exceptional knowledge of
experimental organic chemistry including thorough experience with modern methods for
synthesis, purification and characterization of organic molecules. Prior experience of
macrocycle synthesis would be advantageous but not essential.
? A bachelors degree in organic chemistry with 2-4 years of relevant industrial
? A record of success in the execution of new synthetic routes, application of these
approaches to the synthesis of complex intermediates and novel final molecules
? Evidence of an ability to deliver difficult target molecules. Specifically, a proven
ability to be successful in compound synthesis, troubleshooting problematic
routes and delivering required compounds in a timely manner, in suitable yield
? Experience of compound purification techniques including preparative hplc
? Excellent organizational and communication skills
? The ability to function in a dynamic and interdisciplinary team
Please submit your resume directly to firstname.lastname@example.org.
Be sure to include the title of the job that you are applying for in the subject line of your
No phone calls please.
Ensemble Therapeutics is an equal opportunity employer.
About Ensemble Therapeutics
Based in Cambridge, MA, Ensemble Therapeutics Corporation is a venture backed drug
discovery and development company, developing a novel class of therapeutics, called
EnsemblinsTM. Based on their distinctive macrocyclic structures, Ensemblins are able to
address drug targets, including protein-protein interactions, that are currently inaccessible
with conventional small molecule drugs. By combining the company?s proprietary DNA-
-?Programmed Chemistry (DPC?) drug discovery platform with its highly efficient
affinity selection methodology and specialized discrete macrocycle synthesis capabilities,
Ensemble is the first organization to successfully and reliably engineer vast numbers of
diverse synthetic macrocycles for drug discovery, and to rapidly deliver potent
macrocycle leads and lead series across multiple disease areas. Ensemble is pursuing a
business strategy to develop Ensemblins through its own internal programs and through
partnerships such as those with Genentech, Boehringer Ingelheim, Alexion and Novartis.
Ensemble is backed by notable venture firms including Flagship Ventures and ARCH
Ventures, and is led by highly experienced Big Pharma and biotechnology veterans.
||99 Erie Street |
Cambridge, MA 02139