LC/MS Analytical Chemist / Program Manager Stemina Biomarker Discovery
Stemina Biomarker Discovery?s pioneering cell based assays arise from the strategic convergence of
the groundbreaking technologies metabolomics and human embryonic stem cells. Stemina is
additionally developing a diagnostic platform utilizing metabolomics and human patient samples to
understand the metabolic mechanisms involved in health and disease. Stemina discovers and
validates biomarkers for high throughput diagnostics, drug screening, and toxicology testing in
human systems. Metabolomics enables the discovery of small molecules that can be used as
therapeutic agents or candidate biomarkers of pharmacological efficacy or toxicity. For example, the
human embryonic stem cell metabolome provides a source of candidate biomarkers to predict,
diagnose or measure the progress of disease or toxic response. Stemina provides drug screening,
drug discovery and diagnostic development services for the government as well as pharmaceutical
and biotechnology companies under service contracts or joint discovery agreements using its
proprietary metabolomics platform. In addition, Stemina has interest in using mass spectrometry
based metabolomics to identify biomarkers for a number of diseases including cancer, autism and
The Analytical Chemist will design and execute experiments using HPLC/UPLC, ESI-TOF-MS, MS-MS
mass spectrometry to separate, detect and identify small molecules (candidate biomarkers) in vitro
(human embryonic stem cells) and in vivo (human serum, urine, CSF, saliva, etc) as a result of
pharmaceutical toxicity or disease. The Analytical Chemist reports to the Director of Bioanalytical
Technologies who oversees experimental design and execution and determines strategic goals and
deliverables for the Bioanalytical Technologies department. Upon learning the systems at Stemina,
the individual will also have the opportunity to serve as a project leader for client facing programs.
Essential Job Duties and Responsibilities
? Preparation of biological samples for metabolomics analysis using LC-HRMS
? LC-HRMS data acquisition and analysis of large sample sets in support of metabolomics
? Perform complex analytical methods on biological matrices, often involving problem solving
? Perform tasks related to troubleshooting and maintenance of the equipment as well as
general upkeep of the laboratory.
? Develop protocols and ensure that the protocol and report, including any changes are in
compliance with the appropriate SOPs, GLP, and regulatory guidelines.
? Serve as a technical resource to support grant proposals and reporting; contribution to
intramural grant applications (writing and reviewing).
? Lead efforts with the study team to troubleshoot and solve assay problems as necessary.
? Ensures that all experimental data, including observations of unanticipated responses to the
test system, are accurately recorded and verified.
? Provides leadership to ensure project completion and on time delivery of high quality data
? Co-authors scientific papers/posters which are published or presented at scientific meetings.
Job Title: LC/MS Analytical Chemist / Program Manager Job Code: 03-12
Location: Madison, WI
Reports To: Director FLSA Status: Exempt
Direct Reports: TBDPage 2 of 2
? Development of protocols and ensuring that the protocol and report, including any changes
are in compliance with the appropriate SOPs, GLP, and regulatory guidelines.
? Project Leader responsibilities will include serving as overall leader for studies assigned
including client interaction and internal conduct of a study, as well as, for the interpretation,
analysis, documentation, and reporting of results on commercial metabolomics projects.
Education and Experience:
BS in chemistry, biochemistry or a related field with a minimum 5 yrs experience or MS Degree with
minimum 2 yrs relevant experience in the area of applied analytical chemistry. CRO and/or project
management experience is preferred.. Critical experience must include a strong knowledge of liquid
chromatography separation techniques including ESI- LC-MS. Experience with HRMS, TripleQuadrupole quantitation and/or MS-MS for qualitative compound identification is highly desirable.
Skills and Abilities Required:
? Oral and written communication skills with proven skills in data interpretation and report
? Proficient computer skills: knowledge of Microsoft Windows operating systems and
software, including MS Office and research software programs. This includes the ability to
work and manipulate data in a multi-computer LAN/Server environment.
? Excellent interpersonal skills and demonstrated ability to work on cross-functional teams
? Ability to maintain high level of confidentiality
? Ability to effectively communicate with all levels of the organization
? Ability to work in diverse teams that include cell biologists, physicians and computer
? Ability to manage multiple projects and multitask daily activities
? Creative thinking for problem-solving and development of intellectual property
? Familiarity with regulatory agency (EPA, FDA, CLIA etc.) guidelines and GLP or GMP
industry standards for bioanalytical analysis.
? Demonstrated proficiency in project management skills.
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