Pharmacogenomic Scientist AssureRx
Assurex Health is a personalized medicine company dedicated to helping clinicians determine the right
medication for individual patients with medical conditions. Assurex Health?s proprietary technology is
based on pharmacogenomics ? the study of the genetic factors that influence an individual?s response to
drug treatments ? as well as evidence-based medicine and clinical pharmacology.
The company was founded in 2006 to commercialize industry-leading personalized medicine technology.
Cincinnati Children?s Hospital Medical Center and Mayo Clinic are equity holders and technology
The Pharmacogenomic Scientist is trained in human genetics and molecular biology, and has experience
in the analysis of DNA sequences and modifications using next generation sequencing (NGS) and other
innovative technologies. The candidate will work with a larger research team to obtain from the
literature, internal clinical research results, and other sources candidate genes that impact responses to
CNS medications. Analyze genomic sequence variants and associated data to confirm known and
propose novel associations with medication responses. The Scientist will help design experiments that
evaluate these associations using DNA obtained from clinical studies, as analyzed with custom SNP
arrays, NGS, brain biomarkers, and other deep sequencing platforms. The Pharmacogenomic Scientist
will help establish and maintain relationships with academic and gov?t collaborators and access to DNA
and clinical records. The Pharmacogenomic Scientist will help compose combinatorial gene variant
panels, and design experimental plans suitable for statistical analysis for these evaluations.
? Identify DNA sequencing/modification techniques and CROs/laboratory collaborators to conduct
these analyses for new and enhanced products.
? Design and complete with collaborators exploratory research approaches that elucidate PGx
associations of known and novel genes.
? Define metabolism of psychotropic and other CNS-active medications through literature and other
? Ph.D. required in relevant area
? Knowledge of neuropharmacology
? Familiarity with psychiatric disorders and their treatment
? Experience with how genomic variants effect responses to CNS medications
? Statistics and experimental design
? Understanding how multiple genetic variants can alter single gene function
? Understanding of how variations in multiple genes predict disease or medication response
? Interest in working in a dynamic biotechnology environment
? Excellent interpersonal and communication skills
? Passion for improving health care
? Team-oriented interpersonal communication skills
? Must be analytical, flexible, innovative, and self-motivated
? Must have the flexibility to work extra hours to meet departmental goals
||Mason, OH |