Post Doctoral Scientist 1 Acceleron Pharma
Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel protein therapeutics for cancer and rare diseases. The company is a leader in understanding the biology of the TGF-? protein superfamily, a large and diverse group of molecules that are key regulators in the growth and repair of tissues throughout the human body, and in targeting these pathways to develop important new medicines. Acceleron has built a highly productive R&D platform that has generated innovative clinical and preclinical protein therapeutic candidates with novel mechanisms of action. These protein therapeutic candidates have the potential to significantly improve clinical outcomes for patients with cancer and rare diseases.
The company completed its initial public offering in September of 2013. The company employs approximately 80 ? 90 employees at its Cambridge, MA facilities and has a market capitalization of approximately $1 billion.
We are seeking a highly motivated individual with expertise in hematology research to join our preclinical group as a post-doctoral fellow. The successful candidate will become an integral part of the discovery group focused on identifying novel therapies in TGF- ? family. The candidate will preferably have experience and knowledge in models of anemia such as thalassemia, sickle cell disease or myelofibrosis. Candidate will use these models to establish pre-clinical proof of concept for internal programs. This will include assessment of efficacy and understanding their mechanism of action. Experience in red cell membrane biology and various hematological malignancies will be a plus. Candidate must have an innovative entrepreneur attitude towards discovery research. He/she should be hands on individual and create an environment of mutual respect, encouragement and team work.
Responsibilities include and are not limited to the following:
Key responsibilities will include development of customized, program specific animal models of hematological disorder
Will design new in-vivo and in-vitro experiments to understand the mechanism of action of new therapeutics
Develop assays to validate PD and predictive biomarkers
Expertise in histopathology and immune histochemistry
Quantitative analysis of data and follow up on results
Organize reports and communicate results from experiments to project team and senior management
Flexible team based attitude suitable for an entrepreneur discover research environment
Ph.D. in biology/pharmacology or cell biology
Proficient in techniques in various drug route administration, micro surgery, tissue harvesting, tissue preparation, immunohistochemistry and blood sampling
Proficient in non-invasive imagining system (e.g. bioluminescent imaging), cell culture and various biochemical analyses of tissues (e.g. Taqman analysis, RT-PCR, Western Blots, etc.)
Excellent organizational skills, attention to details and ability to work independently
Quality of self-motivation and strong interpersonal communication skills
Demonstrated ability for creative thinking and problem solving
Demonstrated ability to work in a team oriented environment
Knowledge of red cell membrane biology is a plus
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