Principal Scientist Pharmacology EnVivo Pharmaceuticals
THIS JOB HAS EXPIRED We seek a highly team-oriented and motivated individual who will be a key contributor to the overall success of the Research Department. The Principal Scientist, Pharmacology will report to the Senior Director, Pharmacology. He / she will provide scientific leadership to ongoing novel small molecule drug discovery projects in the area of pharmacology. The candidate will participate in the team of pharmacologists, behavioral pharmacologists, medicinal chemists, and DMPK experts, evaluating drug efficacy in existing animal models and direct the development of novel pharmacological animal models. In addition, the Principal Scientist will work in project teams with other group members.
Contribute in program teams to advance existing small molecule CNS drug discovery programs as well as initiate new efforts to establish new animal efficacy endpoints
Work with Research leadership team to identify and implement additional competencies and approaches fitting current and novel drug discovery programs
Build, together with the Head of Pharmacology, the newly established pharmacology group and hire key individuals
Demonstrate excellence and creativity assessing in vivo drug performance including target binding / engagement, microdialysis, imaging, biomarker / metabolic and physiological approaches.
Develop pharmacological CNS models with validity for human neurological and psychiatric diseases.
Represent function in cross functional program teams beyond research
PhD degree in pharmacology, pharmacy, or related discipline with at least 8+ years of experience in the pharmaceutical / biotech industry. Majority of that experience must be in CNS disorders. Must have experience in leading / training a small pharmacology group. The successful candidate has a breath of experience with pharmacological modeling of human CNS disease in animals (rodent, primate). Strong expertise in in vivo and ex vivo binding and physiological studies required. Minimal experience in ion-channel targets combined with electrophysiology. Experience with in vivo imaging approaches a plus, as is expertise in animal biomarker and metabolic marker pre-clinical development. Seeking proven track record of scientific rigor through publications. Must have very good communication skills and must embrace team work managing various internal and external activities.
||Watertown, MA |
THIS JOB HAS EXPIRED