Scientist - Analytical Sciences/Preclinical and Clinical Development Sciences - Code AS-006 Ardelyx
Ardelyx targets specific gut transporters and receptors with drugs that address important
medical issues in cardiovascular and gastrointestinal (GI) diseases, diabetes and
chronic kidney disease. With its approach, Ardelyx has developed drug candidates that
exhibit restricted absorption across the GI epithelia, thereby acting locally and
specifically in the GI tract while avoiding systemic exposure and the potential for related
systemic side effects. At Ardelyx, you will experience an innovative and dynamic
research environment. You will be working with some of the industry's best scientists in a
team environment focused on world class research. We offer competitive compensation
and benefits including pre-IPO stock options. Ardelyx?, Inc. is an Equal Opportunity
As a member of the Analytical Sciences/PCDS group at Ardelyx, you will join a team
supporting ongoing discovery, preclinical, and clinical activities from the perspective of
bioanalysis, PK-ADME, mineral determination, and support of drug substance and drug
product development. You will serve on multidisciplinary project teams focused on the
discovery and development of new medicines. Analytical Sciences/PCDS works in close
collaboration with biology, pharmacology and medicinal chemistry, while managing
multiple outsourced projects. Successful candidates will contribute directly to the
success of the company across all development programs. The group?s support of
outsourced GLP, clinical, and CMC functions, creates opportunities for exposure to
different aspects of drug development. The ideal candidate is team-focused and adept
moving rapidly between laboratory techniques in a dynamic environment.
Responsibilities include, but are not limited to:
? Analysis of scientific data, interpretation, and communication in well-written reports
? Timely communication of laboratory results to project teams and project leaders
? Operate, troubleshoot, and maintain LC-MS/MS and other analytical equipment.
? Design and execution of cell monolayer permeability studies
? Development & application of quantitative LC/MS/MS methods for PK-ADME studies.
? Preparation and quantitative analysis of chemical and biochemical samples.
? Design, execution, and interpretation of DMPK/metabolite ID experiments
? Manage the timely completion of work supporting clinical development at CRO?s
? Interpretation and presentation of bioanalytical data.
? Evaluation of pharmaceutical properties using HPLC, dissolution, solubility, etc.
? Additional tasks as needed to meet team goals.
? Self-motivated & independent with a graduate degree in the life or chemical sciences
? At least four years? experience in the biotechnology or pharmaceutical industry, with at
least two years at the scientist level? Ability to evaluate scientific questions using a variety of experimental approaches
? It is critical that the candidate have excellent written and verbal communication skills
? Flexibly contribute to team goals in a fast-paced and dynamic environment.
? Experience working with CROs and familiarity with GLP/GMP processes a plus
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