Senior Research Associate - DMPK EnVivo Pharmaceuticals
Will design, coordinate, and execute preclinical pharmacokinetic studies to support small molecule structure-based drug discovery and development for treatment of neurodegenerative diseases; establish, design and conduct in vitro experiments using cell culture techniques and maintain immortalized, transfected and primary cell lines; create database systems for use in calculating cellular permeability and the uptake of compounds; establish and validate assays for drug transporter interaction estimation; work with liquid chromatography and mass spectrometry and related bioanalytical methods for routine ADME sample analysis; perform and analyze data from in vitro enzyme kinetic studies for pharmacokinetic and drug metabolism studies; collaborate and coordinate with CRO for preclinical studies; organize and review experimental write-ups and study reports from CROs; analyze, interpret and communicate preclinical study data with project teams; utilize knowledge of drug discovery screening and high-throughput methods, as well drug metabolism principles; and conduct hands-on research to acquire, implement, and execute assays to support our lead optimization activities.
Master of Science degree in Biochemistry, Molecular Biology, or Biological Sciences (willing to accept foreign education equivalent) as well as 2 years of experience in Job Offered or 2 years of experience in designing and conducting in vitro permeability and transporter experiments in Caco-2 cells. Experience must include: Demonstrated Expertise (?DE?) performing in vitro transporter studies in transfected cells and membrane vesicles, including use of radiolabelled compounds and radiochemical detection techniques for these studies; DE working with Caco-2 cells and performing permeability assays and drug transporter interaction studies using these cells; performing in vitro ADME studies including metabolic stability estimation in subcellular fractions, drug metabolising enzyme based drug-drug interaction studies and plasma protein binding assays; DE performing bioanalysis using liquid chromatography and mass spectrometry (LC/MS/MS). EnVivo Pharmaceuticals, Inc. is willing to accept a suitable combination of education, training and experience to satisfy the requirements.
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Watertown, MA 02472